Experimental cortical spreading depression induces NMDA receptor
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Possible mechanism of tolerance to ketamine-induced blockade of cortical spreading depression
Ketamine (KET) induced blockade of cortical spreading depression (CSD) declines with repeated KET applications in a way suggesting the development of tolerance. Possible mechanism of this process was studied in 31 rats anestheized with pentobarbital. CSD was elicited by injection of 1µl of 5% KCl into cortex at 15 min intervals and monitored by recording the accompanying slow potential waves....
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تاریخ انتشار 2017